Women’s Health Expert Weighs in on Monoclonal Antibody Therapy for Pregnant Patients

UT Health Austin maternal-fetal medicine specialist recommends monoclonal antibody treatment for pregnant patients who test positive for COVID-19 to lessen risk of serious infection

Written by: Lauryn Gerard

If you test positive for COVID-19 while pregnant and are experiencing mild to moderate symptoms, UT Health Austin maternal-fetal medicine specialist Alison Cahill, MD, MSCI, recommends considering monoclonal antibody infusion therapy within the first 10 days of symptom onset to help lessen the severity of the disease for both you and your unborn baby, which is in agreement with recommendations from the Centers for Disease Control and Prevention (CDC) and the American College of Obstetricians and Gynecologists.

Monoclonal antibody (mAb) therapy, also known as monoclonal antibody infusion treatment, is a way of treating COVID-19 that helps prevent hospitalizations, reduce viral loads, and lessen symptom severity. This type of therapy relies on monoclonal antibodies, which are antibodies that are similar to the ones your body would naturally make in response to infection.

Monoclonal antibodies are mass-produced in a laboratory and are designed to recognize the spike protein on the outer shell of the COVID-19 virus. By targeting the spike protein, these specific antibodies interfere with the virus’ ability to attach and enter human cells. These antibodies help boost the immune system until it can mount its own response. While this therapy can be extremely effective, it is not a substitute for the COVID-19 vaccination.

Dr. Cahill is a maternal-fetal medicine specialist within Women’s Health, a clinical partnership between UT Health Austin and Ascension Seton. She and her colleagues from other Austin-area hospitals announced in early August that the Delta variant of COVID-19 affects pregnant women more severely than the original strain of COVID-19 and has resulted in more hospitalizations.

While the time for vaccination is more important now than ever, Dr. Cahill shares that the spread of misinformation has promoted a concern that COVID-19 vaccines may affect women’s fertility, causing some pregnant mothers to delay vaccination. There is no evidence to suggest the vaccine has any negative effect on future fertility or impacts an unborn fetus.

Learn more about the latest research surrounding the effects of COVID-19 vaccinations on pregnancy and fertility here.

“The truth is that what we’re seeing is that the disease itself is doing horrible things to moms and their unborn kids…For pregnant women in the beginning stages of COVID-19, monoclonal antibodies could mean the difference between life and death,” explains Dr. Cahill.

Whether or not they have been vaccinated, Cahill urges pregnant women who do contract COVID-19 or have been exposed to the virus to immediately reach out to their obstetric provider to discuss the possibility of receiving monoclonal antibodies.

Several monoclonal antibody therapies have been given emergency use authorization by the FDA for treating COVID-19, but monoclonal antibodies have also been used for other conditions, including autoimmune diseases and cancer, for decades.

Austin-area residents can receive monoclonal antibody treatment at Travis County’s Regional COVID-19 Therapeutic Infusion Center with a referral from their healthcare provider. The treatment is typically reserved for high-risk COVID-19 patients or patients who have had a high-risk exposure, designations a healthcare provider can determine.

“You should rely on us to do that legwork for you and figure out what your symptoms are, what your other risk factors are, and the strength with which we would recommend this therapy,” says Dr. Cahill.

With a medical referral, pregnant women and other non-hospitalized individuals who are at high-risk can receive antibody therapy at no cost from the Regional Infusion Center located at Travis County Expo Center. Health leaders still claim even with antibody treatment options, getting vaccinated is the best and most effective way to prevent a severe illness from COVID-19.

About the Partnership Between UT Health Austin and Ascension Seton

The collaboration between UT Health Austin and Ascension Seton brings together medical professionals, medical school learners, and researchers who are all part of the integrated mission of transforming healthcare delivery and redesigning the academic health environment to better serve society. This collaboration allows highly specialized providers who are at the forefront of the latest research, diagnostic, and technological developments to build an integrated system of care that is a collaborative resource for clinicians and their patients.

About UT Health Austin

UT Health Austin is the clinical practice of the Dell Medical School at The University of Texas at Austin. We collaborate with our colleagues at the Dell Medical School and The University of Texas at Austin to utilize the latest research, diagnostic, and treatment techniques, allowing us to provide patients with an unparalleled quality of care. Our experienced healthcare professionals deliver personalized, whole-person care of uncompromising quality and treat each patient as an individual with unique circumstances, priorities, and beliefs. Working directly with you, your care team creates an individualized care plan to help you reach the goals that matter most to you — in the care room and beyond. For more information, call us at 1-833-UT-CARES or request an appointment here.