Adenocarcinoma in Situ

About Adenocarcinoma in Situ

The cervix is the narrow portion of the uterus that forms the passageway between the uterus and vagina. The inner part of the cervix is lined with mucus-producing glandular cells. Disruptions to glandular cell function, usually following human papillomavirus (HPV) infection, cause abnormal cell growth. Adenocarcinoma in situ emerges at the early stage of this growth and can progress to a type of cervical cancer known as adenocarcinoma if left untreated.

Regular Pap tests can screen for precancerous conditions of the cervix, including AIS and cervical intraepithelial neoplasia. After additional testing to confirm your diagnosis, your condition can be proactively managed to prevent progression to cervical cancer.

Symptoms of Adenocarcinoma in Situ

AIS typically presents without noticeable symptoms and is first identified after an abnormal Pap test.

Risk Factors for Adenocarcinoma in Situ

Certain people are more likely to develop AIS following an HPV infection.

Risk factors for adenocarcinoma in situ may include:

• Comorbid conditions: People who are immunocompromised due to an autoimmune condition or immunosuppressive medication may be at greater risk for developing AIS.

Treating Adenocarcinoma in Situ at UT Health Austin

In some cases, AIS goes away without any treatment. In other cases, the abnormal tissue associated with AIS can be removed through a minimally invasive surgical excision. Patients who do not wish to conceive may choose to undergo a hysterectomy, a surgical procedure that involves the removal of the uterus. Your care team will work with you to determine the best course of action.

Care Team Approach

Patients are cared for by a dedicated multidisciplinary care team, meaning you will benefit from the expertise of multiple specialists across a variety of disciplines. Our gynecologic oncologists work alongside a team of women’s health experts, including radiation oncologists, pathologists, radiologists, oncofertility specialists, onco-psychiatrists, genetic counselors, physical therapists, dietitians, social workers, and more, to provide unparalleled care for patients every step of the way.

We collaborate with our colleagues at the Dell Medical School and The University of Texas at Austin to utilize the latest research, diagnostic, and treatment techniques, allowing us to provide you with world-class, personalized cancer treatment. Depending on your specific needs, your treatment may include combinations of surgery, chemotherapy, radiation, and/or immunotherapy or other targeted therapy.

Learn More About Your Care Team