About Gastric Cancer
The stomach is a j-shaped, sac-like organ that holds food and initiates the digestive process by secreting gastric juice before the food is emptied into the first part of the small intestine. Gastric, or stomach, cancers tend to develop slowly over many years. Before a true cancer develops, pre-cancerous changes often occur in the inner lining (mucosa) of the stomach. These early changes rarely cause symptoms and therefore often go undetected. The stomach has five parts and depending on which section the cancer begins in, the symptoms, treatment options, and outcomes may be different.
Types of Gastric Cancer
Gastric cancer is classified according to the type of cells that are involved.
Types of gastric cancer include:
- Adenocarcinomas make up of 90-95% of gastric cancers. These cancers develop from cells that form the innermost lining of the stomach called the mucosa.
- Lymphomas are cancers of the immune system tissue that are sometimes found in the wall of the stomach.
- Gastrointestinal stromal tumors (GISTs) are rare tumors that develop in very early forms of cells in the wall of the stomach called interstitial cells of Cajal. These types of tumors can be found anywhere in the digestive tract but are most commonly found in the stomach.
- Carcinoid tumors devlop in the hormone-making cells of the stomach.
- Rarer gastric cancers include squamous cell carcinoma, small cell carcinoma, and leiomyosarcoma.
Symptoms of Gastric Cancer:
- Indigestion and stomach discomfort
- Feeling bloated after eating
- Mild nausea
- Loss of appetite
- Blood in the stool
- Unintended weight loss
- Stomach pain
- Ascites (buildup of fluid in the abdomen)
- Trouble swallowing
Risk Factors for Gastric Cancer
Men have been identified as having a higher risk of developing gastric cancer than women.
Other common risk factors for gastric cancer include:
- A diet high in salted, smoked foods and low in fruits and vegetables
- A diet involving foods that have not been prepared or stored properly
- Older age, usually over the age of 65, though it can occur at any age
- Family history of gastric cancer
- Any of the following medical conditions:
- Helicobacter pylori(H. pylori)infection of the stomach
- Chronic gastritis (inflammation of the stomach)
- Pernicious anemia
- Intestinal metaplasia, a condition in which the stomach lining is replaced with cells that line the intestine
- Gastric polyps
- Epstein-Barr virus
- Familial syndromes (including adenomatous polyposis)
Treating Gastric Cancer at UT Health Austin
Treatment requires accurate diagnosis and a care plan tailored to the specific type of tumor, the tumor’s location, and the overall needs of the patient. The different behavior of different tumor types helps drive decisions about treatment, which may include combinations of surgery, radiation therapy, and chemotherapy.
Care Team Approach
At UT Health Austin, we take a multidisciplinary approach to your care. This means you will benefit from the expertise of multiple specialists across a variety of disciplines. Your care team will include medical oncologists, surgical oncologists, radiation oncologists, pathologists, radiologists, oncofertility specialists, onco-psychiatrists, genetic counselors, physical therapists, dietitians, social workers, and more as well as other members of the CaLM Care Team who work together to help you get back to the things in your life that matter most to you. We also collaborate with our colleagues at the Dell Medical School and The University of Texas at Austin to utilize the latest research, diagnostic, and treatment techniques, allowing us to identify and utilize new therapies to improve cancer treatment outcomes. We are committed to communicating and coordinating your care with your other healthcare providers to ensure that we are providing you with comprehensive, whole-person care.