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About Anal Cancer

Anal cancer begins when healthy cells in or on the anus change and grow out of control, forming a mass called a tumor. Anal cancer arises between the outer part of the anus and the lower part of the rectum and often causes symptoms such as rectal bleeding and anal pain. Most anal cancers start from the mucosa or the inner lining of the anal canal. Some changes in anal mucosa, known as dysplasia, are harmless at first, but might later develop into cancer.

Types of Anal Cancer

Anal cancers are often divided into two groups, which are sometimes treated differently: cancers of the anal canal (above the anal verge) and cancers of the anal margin (below the anal verge). Squamous cell carcinoma is the most common type of anal cancer. This cancer begins in the outer lining of the anal canal. Cloacogenic carcinomas are a type of squamous cell cancer that develops in the middle area of the anal canal and accounts for about 25% of all anal cancers.

Other cancers include:

  • Adenocarcinoma, which arises from the glands that make mucous located under the anal lining
  • Basal cell carcinoma, a type of skin cancer that can appear in the perianal (around the anus) skin

Symptoms of Anal Cancer:

  • Bleeding from the anus or rectum
  • A lump near the anus
  • A change in bowel habits
  • Pain or pressure in the area around the anus
  • Itching or discharge from the anus

Risk Factors for Anal Cancer:

  • Older age, usually over the age of 50, though it can occur at any age
  • Many sexual partners
  • Engaging in receptive anal sex
  • A history of cancer
  • Smoking
  • Human papillomavirus (HPV) infection
  • Drugs or condition that suppress the immune system

Treating Anal Cancer at UT Health Austin

Treatment requires accurate diagnosis and a care plan tailored to the specific type of tumor, the tumor’s location, and the overall needs of the patient. The different behavior of different tumor types helps drive decisions about treatment, which may include combinations of surgery, radiation therapy, and chemotherapy.

Care Team Approach

At UT Health Austin, we take a multidisciplinary approach to your care. This means you will benefit from the expertise of multiple specialists across a variety of disciplines. Your care team will include specialists that are nationally recognized leaders at the forefront of their fields, including medical oncologists, surgical oncologists, radiation oncologists, advanced practice providers, physical therapists, social workers, dietitians, and more, who work together to help you get back to the things in your life that matter most to you. We also collaborate with our colleagues at the Dell Medical School, The University of Texas at Austin, and the Livestrong Cancer Institutes to utilize the latest research, diagnostic, and treatment techniques, allowing us to identify and utilize new therapies to improve cancer treatment outcomes. We are committed to communicating and coordinating your care with your other healthcare providers to ensure that we are providing you with comprehensive, whole-person care.

Learn More About Your Care Team

Gastrointestinal Cancer

Health Transformation Building, 8th Floor
1601 Trinity Street, Bldg. A, Austin, TX 78712
1-833-UT-CARES (1-833-882-2737)
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Surgical Oncology

Health Transformation Building, 8th Floor
1601 Trinity Street, Bldg. A, Austin, TX 78712
1-833-UT-CARES (1-833-882-2737)
Get Directions